Pro-hormones: Steroids in disguise

I had a few questions lately about pro-hormones, and i need to point out some things here:

  • Pro-hormones are steroids. They are not “more natural” or “less harmful” and as “powerful as the real suff”. They have the same suppressive effect on your own production of testosterone and your semen production, as the “real” anabolic androgenic steroids. If you don’t believe me, just get your testosterone measured, your LH and FSH after you’ve take them. Your androgen receptor in your body doesn’t “see” by what it get’s activated, if it is your own testosterone, or an artificial drug. The downstream effect remains the same.
  • Pro-hormones are untested drugs. Pro-hormones are classified as nutritional supplements. That means that they don’t need to undergo the rigorous testing as drugs do.  Market incidents are monitored and substances get banned when there are too much reports of liver failure or health impairment. That doesn’t make pro-hormones less harmful and they have been banned in most countries for exactly this reason. The lack of scientific studies makes them potentially more harmful.
  • Pro-hormones are 95% waste and 5% effect. Every pro hormone is a substance that needs to be converted by a body enzyme into the “active” substance, which usually mimics a known anabolic steroid or a designer steroid. This conversion is limited by time and dose. Since most those transformations happen in the liver, a big part of the pro-hormone is already detoxified and excreted without any effect on the muscles, but with the potential for liver damage. Have your liver tested while you’re on a “course” and you’ll know.
    Even in medicine this first-pass effect happens. If  testosterone is taken orally in a ideal galenic form, the daily dose is 40mg to 80mg daily, whereas the daily natural production is 4-6 mg per day.
  • Pro-hormones can have unclear effects. They can activate androgen, estrogen or progesteron receptors. The activation has never been systematically and scientifically tested. This means you don’t know what the outcome will be. Do not take the marketing flyers of the vendors at face value, you better stick to public scientific resources like pubmed and search for your compound there.

– Contrary to marketing claims, research to date indicates that the use of prohormone nutritional supplements (DHEA, androstenedione, androstenediol, and other steroid hormone supplements) does not produce either anabolic or ergogenic effects in men.
Brown et al.

– However, within the framework of the research reviewed, over-the-counter oral prohormone supplementation is ineffective at increasing muscle mass or athletic performance. As a result of the potential health concerns that have been raised, the risk to benefit ratio of using these substances orally seems unfavorable.
Ziegenfuss et al.

If you choose to take pro-hormones, don’t claim to be “natural” and be aware of the effects this has on your body.

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